Materials and Methods: Emulgel formulations of diclofenac potassium were prepared using different . subjected to various evaluation parameters such as drug. Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was. Formulation and Evaluation of Luliconazole Emulgel for. Topical Drug Delivery. Dhobale Shankar,* Shelke Gajanan, Jadhav Suresh, Gaikwad.

Author: Voran Nikozragore
Country: Nicaragua
Language: English (Spanish)
Genre: Photos
Published (Last): 26 May 2011
Pages: 230
PDF File Size: 15.59 Mb
ePub File Size: 6.98 Mb
ISBN: 471-9-73859-630-4
Downloads: 97174
Price: Free* [*Free Regsitration Required]
Uploader: Mesar

The trend in inflammation and reduction was similar as observed with the first model, in the respective groups. Please feel free to contact me if you have any questions or comments.

Formulation and evaluation of oxiconazole emulgel for topical drug delivery

All other chemicals and solvents were of analytical reagent grade. The developed emulgels were evaluated for their physicochemical properties like color, homogeneity, consistency, spreadability, pH value, rheological behavior, drug content, drug release and stability. The inflammation in the ear of each rat was noted using Vernier caliper at 1st, 2nd, 3rd and 4th h of treatment.

The aim of present study was to develop an emulgel formulation of clindamycin phosphate using Carbopol or HPMC as a gelling agent. The microemulsion which had highest amount of drug solubility and water uptake in the pseudo ternary phase diagram was chosen for trials on microemulsion.

In both the models, animals treated with aceclofenac emulgel showed inflammation reversal in 2 h of application, resulting in improved inhibition of inflammation ebaluation an effect lasting up to 6 h. The emulgel was applied on the properly shaven skin of rat.

Hence, a microemulsion of Aceclofenac was formulated, which was later formed into an emulgel.

Formulation and Evaluation of Tioconazole Emulgel for Topical Drug Delivery System

Microemulsion formulation aids in improving the drug solubility owing to reduced particle size, improved surface tension and better permeation. It is usually used to treat infections with anaerobic bacteria, but can also be used to treat some protozoal diseases, such as malaria.

Percentage inflammation was calculated as under:. However, further research is warranted focusing on formulation stability and more in vivo studies to substantiate the potential of the emulgel formulation as robust and efficacious topical based drug delivery system of aceclofenac.

The microemulsion when diluted in 1: After a number of trials, microemulsion of aceclofenac was optimized with: A similar effect was observed with the marketed fornulation formulation, which reinforces the proof of efficiency of the marketed gel in delivering diclofenac and reducing inflammation. The protocol designed for animal studies was compliant with the CPCSEA guidelines and was approved by the institutional animal ethics committee.

Drugs are administered topically for their action at the site of application or for systemic effects. A formulation yielding clear and transparent appearance and the one not fodmulation when observed for 24 h was selected for further studies.


The study revealed that the formulation with carbopol shown better release profile than HPMC K4M, depicting carbopol as the better choice of polymer for aceclofenac emulgel. Hence, the topical route would be one of the ideal alternatives to enhance local delivery, bypassing these side effects.

Thus, the microemulsion based aceclofenac emulgel showed promising results as an effective anti-inflammatory topical drug delivery system, in this preliminary investigation. The animal studies were conducted in the animal house, under appropriate care and precautions.

In case of control, inflammation showed an increase till 4 h, followed by a slight reduction. Preparation and evaluation of aceclofenac topical microemulsion.


However, a prominent drawback in formulating gels is difficulty in delivery of hydrophobic drug. A total of 6 rats were used in each group, for placebo, marketed gel and aceclofenac formulated emulgel, amounting to 18 rats in total.

In this regard, the study provides a preliminary comparative efficacy data for both the drugs, providing a foundation for a robust clinical evaluation in future studies. Group II received aceclofenac emulgel equivalent to 2.

The optimized quantity of distilled water was then added drop by drop in the solution with constant stirring at 50rpm on a magnetic stirrer. Cumulative corrections were made to obtain the emupgel amount of drug release at each time interval. All the prepared emulgels showed satisfactory physicochemical properties like color, homogeneity, consistency, spreadability, and pH value.

The aliquots 1 mL were collected at time intervals of 1 h up to 8 h. The aim of present work was to develop and evaluate Oxiconazole emulgel with controlled release.